The Markov Clinic Communications & Outreach Center “CFS/ME=CBIS” is committed to open for world-wide medical audience and patients the access to unique original results of the 12-years (2009-2021) systematic clinical research that allowed to find the true etiological and pathophysiological causes of mysterious pandemic Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) that, as for the first time found, hides the new revolutionary previously unknown diagnosis Chronic Bacterial Intoxication Syndrome© (CBIS).
CBIS is the clinical manifestation of focus of chronic bacterial infection in the kidneys, called as Nephrodysbacteriosis© and which developes predominantly as a result of over-use of antibiotics, often - beginning from childhood, due to: bacterial infections, frequent colds and their purulent-inflammatory complications, anti-bacterial prevention at viral infections and in surgery, due to other motivated and more often unmotivated cases. This long-term research gives such a long-awaited in-depth clinical understanding of the true basic etiological and pathogenetic causes of CFS/ME.
Found for the first time:
1) Under the mask of CFS/ME hides a previously unknown disease, Chronic Bacterial Intoxication Syndrome (CBIS).
2) The main etiological and pathogenetic reason for the development of CBIS (CFS/ME) is the formation of a focus of chronic bacterial infection in the kidneys, which may be in a hidden latent state (Nephrodysbacteriosis©, clinically locally asymptomatic with the development of endotoxicosis and severe general intoxication of the organism with the subsequent development of CBIS) or may flow with signs of an inflammatory process (pyelonephritis). The formation of a focus of chronic bacterial infection in the kidneys in 90% of cases occurs after the use of antibiotics (especially with repeated and long courses).
3) The development of CBIS does not depend on gender, age, conditions and geography of residence, social status, profession.
4) Nephrodysbacteriosis occurs when the mucous membranes of the kidneys by upward path are autoinfected by bacteria from patient’s own intestines or/and from the nasopharynx. In a result of the vital activity of bacteria, endo- and exotoxins are released in the kidneys, that leads to the development of endotoxicosis and severe general intoxication of the organism with toxic damage to various organs and systems - this multi-vector toxic lesion is just the cause of more than 70 clinical symptoms and syndromes of CBIS manifestation.
With Nephrodysbacteriosis is connected the development of most cases of such diseases and diagnoses, associated with CBIS, as atopic dermatitis, eczema, erysipelas and other variants of bacterial toxicoderma, some variants of alopecia (baldness), febrile and pain attacks©, fibromyalgia syndrome, reactive, rheumatoid and gouty arthritis, toxic uveitis, isolated ESR elevation syndrome and many other pathological states, the cause of which remained unknown or reliably not detected.
In connection with the COVID-19 pandemic, it should be forecasted and expected a sharp explosive increase of cases of exacerbation or primary diagnosing of CFS/ME=CBIS, which will mistakenly pass under the mask of post-infectious or post-Covid asthenia (weakness). This should be expected mainly after severe forms of coronavirus infection in patients, who were prescribed massive and long-term courses of antibiotics use, with the subsequent development or exacerbation of their post-antibiotic Nephrodysbacteriosis and CBIS.
In 90-100% of people all over the world, regularly throughout life, the mucous membranes of the genitourinary system and kidneys are autoinfected by enterobacteria and enterococci from their own intestines, by staphylococci and streptococci from the nasopharynx:
a) in about half of the cases, there is an almost complete physiological elimination of bacteria from the mucous membranes in the kidneys; in about 50-60% of clinically healthy infants and in 5-10% of healthy adults (with an anamnesis/disease history without often use of antibiotics) develops Nephrodysbacteriosis;
b) nephrodysbacteriosis, remaining clinically locally asymptomatic, due to the developing endotoxicosis can cause severe general intoxication with the development of CBIS, which was mistakenly called and still is being called CFS/ME;
c) the progression of Nephrodysbacteriosis with the development of latent sluggish chronic pyelonephritis and with the gain of manifestations of CBIS is largely connected with the local immunity of the mucous membranes (less - with the general immunity of the organism);
d) after the use of antibiotics, especially by repeated and long courses, in 90-95% of children and adults due to a post-antibiotic disorder of local immunity of the mucous membranes of the kidneys, arises and progresses a focus of chronic bacterial infection in the kidneys (Nephrodysbacteriosis or pyelonephritis), which earlier or later in divers patients is the etiological and pathogenetic cause of the subsequent development of CBIS.
According to the Markov Clinic’s experience in the diagnostics and treatment of CBIS (CFS/ME) in 4500 children and adults, CBIS is diagnosed in 90-95% of all primary cases of CFS/ME, so diagnosed outside/before the Markov Clinic, and in 95-100% of direct visits to the Markov Clinic with symptoms of CFS/ME. Successful treatment of CBIS (CFS/ME) with 95-97%-efficiency and with full recovery was achieved in all patients diagnosed with CFS/ME. Clinical, bacteriological, toxicological diagnoses and treatment schemes are described in the research work "Chronic Bacterial Intoxication Syndrome under the mask of CFS/ME".
The full version of this work consists of Reports 1-9.
Reports 1-6 “Clinical Diagnosis” (total 85 pages) with open access are already published in the proceeding book of the Joint Event on 8th International Congress on Infectious Diseases (February 15-16, 2021, Webinar, “8th Infection Congress, 2021”, London, UK) – in the open-access-Journal of Infectious Diseases & Preventive Medicine (Longdom Publishing), 2021, Volume 9 / Conference Proceedings (Scientific Tracks Abstracts), namely under: https://www.longdom.org/proceedings/chronic-bacterial-intoxication-syndrome-under-the-mask-of-cfsme-59051.html.
Comments for 3.:
the final diagnostics and recommended treatment of CFS/ME (CBIS) may be carried out/prescribed also during the personal visit to the Markov Clinic / Vitacell Clinic, Kyiv, Ukraine.
In this case the payment for a such personal consultation (in the same amount as per 3.) may be paid directly at the Markov Clinic / Vitacell Clinic.
Registration for the personal consultation takes place via:
* Email: email@example.com or Telegram (+38 097 951-87-51).
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